Researchers will grow a trial crop of potatoes genetically modified to resist infection by potato cyst nematodes.
DEFRA granted approval to scientists from Leeds University following a public consultation.
The crop will be grown this year.
Experts from the government's Advisory Committee of Releases to the Environment (ACRE) evaluated the application (PDF).
The committee said it was satisfied that the proposed trial would not result in any adverse effect on human health or the environment.
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